After 4 h incubation at room temperature, the sample concentration in the donor and acceptor wells were measured using a UV-Vis spectrophotometer (Beckman, DU640) set at the wavelength corresponding to the maximum absorption of each compound
Purity: Refer to current batch COA
Tables 1 and 2 summarize passive membrane diffusion and active transport membrane permeability, respectively, for select small molecule NNMT inhibitors for which structure activity relationships had been previously developed.[17] 1-MNA, a product inhibitor of NNMT[12, 24, 25] exhibited no passive permeability (Table 1)
Reported / Possible Side Effects Mild, anecdotal: Occasional reports of mild headache, transient jitteriness, or injection-site reactions
By blocking this enzyme, researchers can observe a significant shift in cellular methyl-donor availability